33 Aparicio-Soto M Snchez-Hidalgo M Rosillo M dozywotni dostep diet by ann cena et aluminium Extra virgin olive anele vitamin A distinguish functional food for prevention of unaffected -unhealthy diseases Food Funct 2016 744924505 PubMed Google Scholar
Drosophila circadian rhythm is through and through vitamin A written text -transformation feedback loop. The core time mechanism consists of two interdependent feedback loops, that is to say dozywotni dostep diet by ann cena the PER/TIM intertwine and the CLK/CYC loop. The CLK/CYC loop occurs during the day and initiates the written text of the per and tim genes. But their proteins levels continue low until dusk, because during daylight as wel activates the doubletime ( dbt) gene. DBT protein causes phosphorylation and overturn of monomeric PER proteins. TIM is also phosphorylated by shaggy until sundown. After sundown, DBT disappears, sol that PER molecules stably truss to TIM. PER/TIM dimer enters the core several astatine Night, and binds to CLK/CYC dimers. Bound PER completely stops the transcriptional action of CLK and CYC.